Twists are good to hand out when they’ve accumulated a bunch of conditions —*because if you don’t twist, there’s a chance you’ll repeat a condition and then the character gets off scot-free! And if you pick a more serious condition, you might kill the character for a dumb reason (“You pick up the scroll to read it and get a paper cut—take Injured.”).
You can use the Good Idea rule to finetune the amount of soul-crushing you’re inflicting on your players. If it gets too much and threatens to turn from fun to no longer quite fun, you can provide some breathing room by being a bit more generous with Good Ideas.